Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening: Reducing the Risk of Drug-Induced QT Interval Lengthening in Women

Recruiting
21 years - 100 years
Female
Phase N/A
1 Location

Brief description of study

The purpose of this study is to determine the effectiveness of progesterone given by mouth for minimizing drug EKG response to a drug.

Detailed description of study

Our objective is to evaluate and compare the efficacy of novel therapeutic approaches to reduce the risk of drug-induced QTc interval prolongation and TdP.
Participants will be paid for their participation.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: healthy,Torsades de pointes,menopause
  • Age: 21 years - 100 years
  • Gender: Female

Inclusion Criteria
Postmenopausal women, based on the following criteria:
Age 50 years of age or older AND

No menstrual periods for 365 days or longer
 
Premenopausal women:
21-40 years of age
 

Exclusion Criteria
History of breast, ovarian or uterine cancer
Taking hormone replacement therapy
Heart failure due to reduced ejection fraction (left ventricular ejection fraction 40%)
Family or personal history of long-QT syndrome, arrhythmias or sudden cardiac death
Concomitant use of any QT interval prolonging drug
Permanently paced ventricular rhythm

Updated on 04 Aug 2024. Study ID: 1806935117

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