Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma

Recruiting
18 years - 50 years
Male
Phase N/A
1 Location

Brief description of study

This research trial studies saliva, semen, and blood samples to determine effects of chemotherapy on fertility in osteosarcoma survivors. Study biospecimen samples from osteosarcoma survivors in the laboratory may help doctors learn whether chemotherapy causes fertility problems and to learn more about the long term effects.

Detailed description of study

The purpose of this study is to determine whether infertility and/or biomarkers of spermatogenesis and steroidogenesis differ in male osteosarcoma survivors treated with cisplatin with or without ifosfamide compared to male controls without a history of cancer, and to evaluate whether cisplatin with or without ifosfamide for the treatment of osteosarcoma alters sperm deoxyribonucleic acid (DNA) methylation.
Participants will not be paid for their participation.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: osteosarcoma,bone cancer,cancer,oncology
  • Age: 18 years - 50 years
  • Gender: Male

Inclusion Criteria
Previously enrolled and randomized on AOST0331 or INT0133 (also known as CCG7921 and POG9351)
Osteosarcoma survivors without relapse or a subsequent malignancy other than skin cancer following initial treatment on AOST0331 or INT0133 (also known as CCG7921 and POG9351)
Able to speak, read and write in English or Spanish

Updated on 04 Aug 2024. Study ID: 1712550596 (PHO-PRADHAN-COG-ALTE16C1)

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