Neural Mechanism of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait

Recruiting
40 years - 85 years
All
Phase N/A
40 participants needed
1 Location

Brief description of study

To investigate the treatment effect of Theta-burst Transcranial Magnetic Stimulation (TBS) on patients with freezing of gait (FOG) and the underlying neural mechanism.

Detailed description of study

This was a open-label clinical trial. Forty patients with FOG were treated with TBS for 5 days. Each patient was given a high-dose iTBS of 9000 pulses/day for each target to stimulate the lower extremity motor area and dorsolateral prefrontal lobe respectively. The stimulation sequence of the two targets was randomized among subjects, and the stimulation sequence within the subjects remained unchanged throughout the course of treatment for 5 consecutive days (18000 pulses/day, 90,000 pulses in total).

Before the TBS treatment, the Freezing of Gait Questionnaire, the Timed up and go test, the Standing Start 180° Turning Test, the Unified Parkinson's Disease Rating Scale, and the Non-motor Symptom Scale, the Pittsburgh sleep quality index were obtained by a trained investigator to assess baseline severity. The patients had receiving a battery measure of neuropsychological tests(mini-mental state examination, Montreal cognitive assessment, digital span test, verbal fluency test, Hamilton depression/anxiety scale) and magnetic resonance imaging (MRI) scan in multimodalities, electroencephalography (EEG) record, and biological specimens (blood, urine, etc.). In the second day after the last treatment, all the tests, MRI, EEG and biological specimens were reassessed. Patients were instructed to focus their answers on the past 5 days.

The clinical symptom and cognition of participants were followed in one month and two month after the last treatment.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Transcranial Magnetic Stimulation, Freezing of Gait
  • Age: 40 years - 85 years
  • Gender: All

Inclusion Criteria:

  1. diagnosis of FOG with expertise in movement disorders.
  2. the score of item 3 of the FOG questionnaire ≥1.
  3. ongoing treatment with a stable dose of any medication for 2 months.
  4. 40 years of age or older.

Exclusion Criteria:

  1. a history of addiction, psychiatric disorders, or neurological diseases other than PD.
  2. focal brain lesions on T1-/T2-weighted fluid-attenuated inversion recovery images.
  3. anti-PD medication adjustments during rTMS treatment.
  4. history of substance abuse within the past 6 months.
  5. nonremovable metal objects in or around the head.
  6. previously received rTMS treatment.
  7. prior history of seizure or history in first-degree relatives.

Updated on 22 Nov 2022. Study ID: AHMU-TMS-FOG-twotargets

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