A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Recruiting
18 years - 100 years
All
Phase 2/3
5 participants needed
1 Location

Brief description of study

The purpose of this study is to compare concurrent reduced-dose radiation therapy (RT) with cisplatin or concurrent reduced-dose radiation therapy with nivolumab to the current standard of care (standard-dose RT with cisplatin).

Detailed description of study

Participants will be randomly assigned to receive radiation plus either cisplatin or nivolumab.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Oropharyngeal Cancer
  • Age: 18 years - 100 years
  • Gender: All

Individuals at least 18 years of age with squamous cell carcinoma of the oropharynx.

Individuals with lifetime cumulative smoking history exceeding 10 pack-years will not be eligible.

Individuals with severe, active co-morbidity will not be eligible.

Women who are pregnant will not be eligible.

Updated on 04 Aug 2024. Study ID: 1912360365

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