GSNOR Phenotyping/GSNO Challenge in Severe Asthma

Recruiting
18 years - 50 years
All
Phase N/A
1 Location

Brief description of study

This is a three to four visit study, spanning approximately two to six weeks, in which subjects with asthma and healthy volunteers will undergo screening, baseline characterization, a research bronchoscopy, and a non-invasive challenge test with inhaled GSNO followed by repeated measurements of airway function and inflammation.  

Detailed description of study

Asthma is common but some people don’t respond to traditional treatments. This could be
because some asthma patients have high levels of a protein (GSNOR) that reduces the amount
of a chemical that relaxes airway muscles (GSNO) in their body. This can lead to the airway
muscles tightening which can cause symptoms like coughing, wheezing and shortness of
breath. There may be drugs that can target this process but first we must identify which patients
have high levels of this protein. We are developing a practical method to do just that.
For more information, call us at 317-274-3380 or email IUasthma@iupui.edu

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: asthma
  • Age: 18 years - 50 years
  • Gender: All

The GSNO Study is for people with asthma  who also:
- Are 18 – 50 years old
- Have had no recent flares
- Have had no recent change in medication
- Are available for 3-4 clinic visits over 2-6 weeks

Updated on 04 Aug 2024. Study ID: 1904630156

Pre-Screener

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Take up this questionnaire to help us determine if you have symptoms that are common to this clinical study. If you have the common symptoms, you may be eligible to take part in the study.

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