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Found 206 Neoplasm trials

A listing of Neoplasm medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Featured study
Phase II trial of retroperitoneal lymph node dissection as first-line treatment for testicular seminoma with isolated retroperitoneal disease (1-2cm)

Phase II trial of retroperitoneal lymph node dissection as first-line treatment for testicular seminoma with isolated retroperitoneal disease (1-2cm)

A
Abdulkader Sinno
A
A. John Spittler, RN
1 month - 12 months
Accepts healthy volunteer
All genders
Phase 2
The purpose of this study is to evaluate the safety and effectiveness of Retroperitoneal Lymph Node Dissection (RPLND) as a treatment option for seminoma that has gone to the lymph nodes in the retroperitoneum. 
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Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations

Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations (NEOASIS)

18 years - 90 years
Accepts healthy volunteer
All genders
Phase 2/3
In this study, the efficacy of botensilimab and balstilimab in mismatch repair deficient (dMMR) and mismatch repair proficient (pMMR) tumors will be assessed.
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Online study

Social Prescriptions and Micro-Learning to Improve Care for Cancer Patients and Their Support Persons (PRISMA)

18 years or above
Accepts healthy volunteer
All genders
Optimal patient-centered care is often not being delivered to cancer patients, especially to vulnerable populations like those living in underserved rural areas. This body of work will develop and pilot test a multicomponent intervention approach designed to improve the care and outcomes of cancer patients and their support persons (SPs) …
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A Phase II Study Analyzing Pre-Operative Stereotactic Radiosurgery Followed by Resection for Patients with 1-4 Brain Metastases

18 years - 100 years
All genders
This is a prospective, single arm, phase II trial to determine the local control at 6 months utilizing pre-operative stereotactic radiosurgery followed by surgery within 1 - 3 days in subjects with a diagnosis of 1-4 brain metastases and with an indication for surgical resection of at least one brain …
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A pilot phase 2 study evaluating dose de-escalation in whole brain radiation therapy with simultaneous integrated boost for patients with brain metastases

18 years - 100 years
All genders
This trial is a pilot, Phase 2, sequential two-cohort study designed to test two de-escalated whole brain radiation therapy (WBRT) dose levels and assess their ability to maintain acceptable in-brain distant control.
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Assessing tobacco use and cessation support among patients with non-tobacco related cancers

18 years - 100 years
All genders
The purpose of this study is to estimate how many patients currently smoke tobacco who are diagnosed with breast, colon, and prostate cancer, to understand what patients know about the harms of continuing to smoke, and to learn about any previous efforts to quit.
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Collection of Specimens and Clinical Data to Create a Biorepository for the Genitourinary Oncology Program

18 years - 100 years
All genders
The purpose of this study is to collect a variety of blood and cancer tissue specimens from patients with advanced kidney, bladder or prostate cancer.
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A Phase 1 Study Of Ramucirumab a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor-2 (VEGFR-2) Receptor in Children With Refractory Solid Tumors Including CNS Tumors

1 years - 21 years
All genders
The main purpose of this study is to evaluate the safety of the study drug known as ramucirumab in children with recurrent or refractory solid tumors including central nervous system (CNS) tumors.
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A Phase 1 First-in-Human Open-label Study Evaluating the Safety Tolerability Pharmacokinetics and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With a Specific KRAS Mutation.

18 years - 100 years
All genders
This research study is being done to test the effects of a new investigational drug therapy called AMG 510 which is being investigated for the treatment of advanced solid tumors with a specific KRAS mutation.
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A Phase 1 Study of Selinexor (KPT-330 IND#125052) a Selective XPO1 Inhibitor in Recurrent and Refractory Pediatric Solid Tumors Including CNS Tumors.

1 years - 21 years
All genders
The investigators will conduct a phase 1 trial of Selinexor in children with recurrent or refractory solid tumors, including CNS tumors using the Rolling Six design. The aims of the trial will be to establish the maximum tolerated pediatric doses of tablet formulation; to investigate the toxicities, pharmacokinetics, and pharmacodynamics …
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