Role of keratinocyte-derived cytokines in epidermal injury and atopic dermatitis

Recruiting
21 years - 100 years
All
Phase N/A
1 Location

Brief description of study

The purpose of this study is to examine a protein from the skin of people with atopic dermatitis and compare with those who do not have this disease.

Detailed description of study

The purpose of this study is to characterize the functions of IL-33 in and on cells in human skin isolated from patients with atopic dermatitis, control patients with psoriasis and healthy subjects.

Participants will be compensated for their participation.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: healthy
  • Age: 21 years - 100 years
  • Gender: All

Inclusion Criteria
For subjects with atopic dermatitis, only patients with active atopic dermatitis will be enrolled
For subjects with psoriasis, only patients with active plaque psoriasis will be enrolled
Exclusion Criteria
Patients without active atopic dermatitis
Patients without active plaque psoriasis
No current or use within the past 6 months of any systemic immunosuppressants including systemic steroids, methotrexate, cyclosporine, azathioprine, mycophenolate mofetil, acitretin, isotretinoin, TNFalpha inhibitors and ustikenumab
No prior use of UVB- or UVA-based phototherapies or tanning beds within the past 3 months
No current or use within the past 1 week of topical steroids, topical calcineurin inhibitors or other toopical medications (other than bland emollients) on the skin sites that will be used for the proposed studies
No history of abnormal scarring
No history of allergy to lidocaine or other amide local anesthetics
No history of systemic immunosuppression or abnormal serious skin infections necessitating hospitalization
No history of bleeding disorders or use of anticoagulants

Updated on 04 Aug 2024. Study ID: 1504431030

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