Functional and Neurochemical Substrates of Chemotherapy-Related Cognitive Deficits
Recruiting
18 years - 55 years
Female
Phase
N/A
1 Location
Brief description of study
The purpose of this study is to understand how chemotherapy alters brain function and brain chemistry.
Detailed description of study
We are looking for breast cancer survivors and healthy women to participate in a study of cognitive deficits. We are working to better understand memory changes after chemotherapy.
Participants will be asked pre-screening questions and screening questions, and pregnancy test to confirm eligibility. Eligible participants will be enrolled in the study that will take place over 1-2 days. The visit will take approximately 4-5 hours of your time, and could be done over 2 days. Volunteers will be reimburse $100 for their time and effort after the study is complete.
Participants will be paid for their participation.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: breast cancer
-
Age: 18 years - 55 years
-
Gender: Female
Inclusion Criteria
Able to complete and understand study questionnaires and procedures in English
Breast cancer survivors with a history of non-metastatic disease and chemotherapy treatment, between 6 months to five years post-chemotherapy completion
OR
Healthy
Exclusion Criteria
Any neurological or other medical disorder which may compromise subject safety or influence study outcomes (e.g., stroke, Parkinson's Disease, epilepsy, high blood pressure, diabetes, liver disease, cardiovascular disease, metastatic brain cancer, dementia)
Women who are pregnant, breast-feeding, or of childbearing potential and not using birth control
Current cigarette or marijuana smoking
Taking any medication in the past 30 days which could influence study outcomes (e.g. dopaminergic psychotropic medications or SNRIs)
Taking prescription opioid medication
Dependence on any drug other than caffeine or nicotine
Having no telephone or a reliable way in which study personnel can contact them
Subjects who are claustrophobic and cannot tolerate imaging procedures
Subjects who are contraindicated for magnetic resonance imaging (MRI) on standard IU screening forms: subjects who have metal implants, surgical devices, or other metal objects that would compromise the subject?s health during the MRI
Subjects who weigh > 350 lb. (upper weight limit of scanner beds)
Able to complete and understand study questionnaires and procedures in English
Breast cancer survivors with a history of non-metastatic disease and chemotherapy treatment, between 6 months to five years post-chemotherapy completion
OR
Healthy
Exclusion Criteria
Any neurological or other medical disorder which may compromise subject safety or influence study outcomes (e.g., stroke, Parkinson's Disease, epilepsy, high blood pressure, diabetes, liver disease, cardiovascular disease, metastatic brain cancer, dementia)
Women who are pregnant, breast-feeding, or of childbearing potential and not using birth control
Current cigarette or marijuana smoking
Taking any medication in the past 30 days which could influence study outcomes (e.g. dopaminergic psychotropic medications or SNRIs)
Taking prescription opioid medication
Dependence on any drug other than caffeine or nicotine
Having no telephone or a reliable way in which study personnel can contact them
Subjects who are claustrophobic and cannot tolerate imaging procedures
Subjects who are contraindicated for magnetic resonance imaging (MRI) on standard IU screening forms: subjects who have metal implants, surgical devices, or other metal objects that would compromise the subject?s health during the MRI
Subjects who weigh > 350 lb. (upper weight limit of scanner beds)
Updated on
04 Aug 2024.
Study ID: 1711139160
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