Profiling of the Gut Microbiome in Overweight Youth with T1D and Associations with Biomarkers of b-cell Stress and Death.

Recruiting
11 years - 18 years
All
1 Location

Brief description of study

Aim 1 of the study is to profile the gut microbiome in youths with type 1 diabetes according to their body mass index. The central hypothesis is that the gut microbiome will be altered in obese vs. lean youths with T1D (and when compared to healthy non-diabetic lean and obese youths) and that this could be related to differences in β-cell stress/death. Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive β-cell loss with eventual dependence on exogenous insulin. Our long-term goal is to understand the role of the gut microbiome in the development of T1D in obese and lean individuals, which would ultimately lead to a more targeted therapeutic approaches in those individuals.
Aim 2 is to determine if differences in the gut microbiome profile are associated with differences in measures of β-cell stress/death.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Healthy volunteers and obese youth.
  • Age: 11 years - 18 years
  • Gender: All

Inclusion:

1)    Obese youths 11-18 years of age with T1D at time of diagnosis and at time of enrollment.
2)    Lean youths 11-18 years of age with T1D at time of diagnosis and at time of enrollment.

 

Exclusion:

1)    Known monogenic forms of diabetes or Type 2 diabetes (confirmed clinically and by genetic/antibody testing).
2)    History of ongoing infection or antibiotic treatment within the past 3 months;
3)    History of immune-compromise, recurrent infections, steroid intake (inhaled or oral forms) or other immunosuppressant use in the past 6 months.
4)    History of chronic gastrointestinal disease, possible or confirmed celiac disease;
5)    Participation in any research intervention trials within the past 3 months.
6)    History of treatment or use of metformin, a type 2 diabetes medication.

Updated on 04 Aug 2024. Study ID: 1908640459

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