Understanding and Predicting Breast Cancer Events After Treatment (UPBEAT)

Inclusion Criteria

Inclusion Criteria for Women with Stage I - III Breast Cancer: 

-Stage I-III female breast cancer (including inflammatory and newly diagnosed or locally recurrent breast cancer) but not metastatic breast cancer being treated with curative intent

-Scheduled to receive chemotherapy

- Able to hold breath for 10 seconds

- Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or fainting

- Able to exercise on a treadmill or stationary cycle

- Participants in other ongoing clinical trials are eligible for this study

Inclusion Criteria for Women Free of Cancer for Comparison:

- Healthy female without known coronary artery disease

- Able to hold breath 10 seconds

- Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or fainting

- Able to exercise on a treadmill or stationary cycle

- No hx. of cancer

- Never received chemotherapy, radiation therapy, immunotherapy, or had breast surgery

Exclusion Criteria

Exclusion Criteria for Women with Stage I-III Breast Cancer:

- Those with ferromagnetic cerebral aneurysm clips or other intracranial metal; pacemakers, defibrillators, functioning neurostimulator devices or other implanted non-compatible MRI devices

- Symptomatic claustrophobia

- At the beginning of the study, pregnant women and women who are breast-feeding will not be enrolled.

- Severe pulmonary hypertension

- Within the past 6 months:

-- Acute pulmonary embolus

-- Deep vein thrombosis

- Within the past month:

-- Heart attack

-- Unstable or stable angina (cardiac chest pain)

-- Left main coronary artery disease

-- Symptomatic heart failure

-- Uncontrolled hypertension (SBP > 180 mm Hg or DBP > 100mm Hg)

-- Severe valvular heart disease

-- Uncontrolled metabolic disease (diabetes with fasting BS >300 mg/dl, thyrotoxicosis, myxedema)

-- Aortic aneurism (>45 mm diameter) or aortic dissection

-- Uncontrolled slow or fast heart rhythm causing symptoms or hemodynamic compromise

-- Hypertrophic obstructive cardiomyopathy

Exclusion Criteria for Women Free of Cancer for Comparison:

- Inflammatory conditions such as lupus or inflammatory bowel disease

- Overt coronary artery disease or heart failure

- Those with ferromagnetic cerebral aneurysm clips or other intracranial metal; pacemakers, defibrillators, functioning neurostimulator devices or other implanted non-compatible MRI devices

- Symptomatic claustrophobia

- At the beginning of the study, pregnant women or women who are breast feeding will not be enrolled.

- Severe pulmonary hypertension

- Within the past 6 months:

-- Acute pulmonary embolus

-- Deep vein thrombosis

- Within the past month:

-- Heart attack

-- Unstable or stable angina (cardiac chest pain)

-- Left main coronary artery disease

-- Symptomatic heart failure

-- Uncontrolled hypertension (SBP > 180 mm Hg or DBP > 100mm Hg)

-- Severe valvular heart disease

-- Uncontrolled metabolic disease (diabetes with fasting BS >300 mg/dl, thyrotoxicosis, myxedema)

-- Aortic aneurism (>45 mm diameter) or aortic dissection

-- Uncontrolled slow or fast heart rhythm causing symptoms or hemodynamic compromise

-- Hypertrophic obstructive cardiomyopathy